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Pregabalin CAS 148553-50-8 : Something You Really Need to Know

1. What is pregabalin CAS 148553-50-8?

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pregabalin CAS 148553-50-8 was originally FDA approved in 2004 as an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.

Pregabalin is used to treat pain caused by fibromyalgia, or nerve pain in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia), or spinal cord injury.

Pregabalin is also used with other medications to treat partial-onset seizures in adults and children aged at least 1 month.

2. Adverse reactions of pregabalin CAS 148553-50-8

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Adverse events are classified by body system and in descending order of incidence.

Systemic common:

abdominal pain, allergic reaction, fever, peripheral edema, edema, abnormal gait, falls, drunkenness, fatigue; rare: abscess, cellulitis, chills, malaise, neck stiffness, drug overdose, pelvis Pain, photosensitivity reaction, suicide attempt, generalized edema, chest tightness, pain, thirst, fatigue; rare: anaphylactoid reaction, ascites, granuloma, hangover effect, intentional injury, retroperitoneal fibrosis, shock, suicide.

Cardiovascular system-rare

deep thrombophlebitis, heart failure, hypotension, orthostatic hypotension, retinal vascular abnormalities, syncope, tachycardia, first-degree atrioventricular block, sinus bradycardia, high Blood pressure, hot flashes, flushing, cold extremities; rare: ST segment depression, ventricular fibrillation, sinus tachycardia, sinus arrhythmia.

Digestive system

gastroenteritis, increased appetite, vomiting, constipation, flatulence, bloating, dry mouth; rare: cholecystitis, cholelithiasis, colitis, dysphagia, esophagitis, gastritis, gastrointestinal bleeding , melena, oral ulceration, pancreatitis, rectal bleeding, tongue edema, gastroesophageal reflux, hypersalivation, oral hypoesthesia; rare: aphthous stomatitis, esophageal ulcer, periodontal abscess.

Blood and lymphatic system

ecchymosis; rare: anemia, eosinophilia, hypochromic anemia, leukocytosis, leukopenia, lymphadenopathy, thrombocytopenia; rare: myelofibrosis, polycythemia, thrombin Original reduction, purpura, thrombocytosis.

Metabolic and nutritional abnormalities

increased appetite; rare: anorexia, hypoglycemia; rare: impaired glucose tolerance, uric acid crystalluria.

Musculoskeletal system

arthralgia, leg cramps, myalgia, muscle weakness, muscle spasm, back pain, extremity pain, neck spasm; rare: arthropathy, joint swelling, muscle twitching, neck pain, myotonia ; Rare: cartilage dystrophy, generalized spasticity, rhabdomyolysis.

 Nervous system

dizziness, somnolence; common: anxiety, depersonalization, increased muscle tone, hypoesthesia, decreased libido, nystagmus, paresthesia, sedation, stupor, twitching, euphoria, confusion, Irritability, depression, disorientation, insomnia, ataxia, dyscoordination, tremor, amnesia, memory impairment, attention disturbance, balance disturbance, lethargy; rare: abnormal dreaming, agitation, apathy, aphasia, perioral paresthesia , dysarthria, hallucinations, hostility, hyperalgesia, hyperesthesia, increased movement, hypokinesia, decreased muscle tone, increased libido, myoclonus, neuralgia, irritability, depressed mood, elevated mood, mood swings, word-calling Difficulty, psychomotor hyperactivity, orthostatic dizziness, intention tremor, cognitive impairment, speech disturbance, hyporeflexia, burning sensation; rare: addiction, cerebellar syndrome, cogwheel rigidity, coma, delirium, delusions, autonomic dysfunction , movement disorders, dystonia, encephalopathy, extrapyramidal syndrome, Guillain-Barré syndrome, hypoalgesia, increased intracranial pressure, manic manifestations, paranoid manifestations, peripheral neuritis, personality disorders, psychotic depression, psychosis Schizophrenia manifestations, sleep disturbances, torticollis, trismus, panic attacks, release of inhibitions, writing difficulties.

3. Precautions of pregabalin CAS 148553-50-8

Diabetic patients

 According to current clinical practice, some diabetic patients need to adjust hypoglycemic drugs when they gain weight due to pregabalin CAS 148553-50-8  treatment.

 Angioedema

In post-marketing reports, some patients developed angioedema after initiation or long-term use of pregabalin CAS 148553-50-8 . Specific symptoms include swelling of the face, mouth (tongue, lips, and gums) and neck (pharynx and throat). Case reports of angioedema leading to life-threatening respiratory injury requiring urgent treatment. This product should be discontinued immediately if the patient develops these symptoms. Patients who have experienced angioedema in the past should be aware of related symptoms when taking this product. In addition, the risk of developing angioedema may be increased when other drugs that cause angioedema (eg, angiotensin-converting enzyme inhibitors [ACEI]) are concomitantly taken.

 Hypersensitivity reactions

In post-marketing reports, some patients experienced hypersensitivity reactions within a short period of time when they started using pregabalin CAS 148553-50-8. Adverse effects include skin redness, blisters, hives, rash, difficulty breathing, and wheezing. This product should be discontinued immediately if the patient develops these symptoms.

4. Where to buy pregabalin CAS 148553-50-8 ?

pregabalin CAS 148553-50-8  is available online from different pregabalin manufacturers. Most users of pregabalin buy from different websites, some for retail or wholesale purposes.

Verify the legitimacy of every pregabalin manufacturer using outlined state laws before purchase.

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